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The weekend sees the initial Wear-Tyne derby after 2024, but who will emerge victorious – the Black Cats or Newcastle?
"For most of last season, no one would have predicted the Wearside club earning promotion and holding their own with Eddie Howe's Newcastle, much less being above them in the table," stated analyst Chris Sutton.
"It is very different now, and the way they play makes me think they've got a genuine opportunity."
Sutton is making predictions for all 380 Premier League games this season, in competition with AI, the public and a assortment of guests.
For this weekend's fixtures, he is challenged by England Gaming star Daniel 'Stingray' Ray.
Ray is vying for victory for the national gaming squad – the Football Association's official esports team – at the football simulation Uefa eEuro 2025 finals tournament, which takes place at Twickenham Stadium on Saturday.
Viewers can catch Uefa's YouTube, IG Live and short-form video channels, as well as the official Twitch channel and its YouTube counterpart and England's Twitch.
Are you in alignment with their forecasts? Share your own predictions below.
The most commonly selected scoreline selected for each game is featured in the scoreboards at the foot of this page.
Predicting the right outcome (choosing a win, draw or defeat) is worth ten points. The exact score earns 40 points.
Ray, who represents Gen City and the Premier League champions as well as England, is making his debut at the eEuros finals after getting through the preliminary stage.
Eight players will play for their countries at the finals in a single-elimination, competing for a six-figure prize fund and a prestigious spot in the FC Pro World Championship Play-Ins, with Denmark's Anders Vejrgang looking to retain the title he won last year.
"I am feeling really good for it," Ray stated. "There's a really good coach alongside me and training has been going well.
"It's always an honour to play for your country. Naturally when you are younger, you imagine doing it as an actual footballer, but when you go into this job and there is an chance to represent England, wearing the Three Lions is something unique.
"I beat Vejrgang 9-4 in qualifying to get here. I've played against him over the course of the season just in practice, and in other tournaments before - but I'd never beaten him in a tournament before.
"I believe he is the top competitor in the world so defeating him in a tournament like this just provides a huge surge of confidence."
Premier League Weekend Preview
Saturday, 13 December
Chelsea vs Everton
Stamford Bridge, 15:00 GMT
Chelsea were impressive against Arsenal at the end of November, when they got a draw after going down to 10 men, and it seemed they've turned a corner, they could possibly be challengers for the crown.
However, since that game, however, they were beaten physically by Leeds, looked uninspired against Bournemouth and this week got defeated by Atalanta in the Champions League.
So boss Enzo Maresca really needs a win here to restore momentum, but it is a tough ask because the Toffees are such a threatening team.
Two of their stars are playing exceptionally and Everton have got a bit of form at the moment.
Current evidence suggests you would probably back the visitors, while the most prudent prediction would likely be a draw, but I am not going to be sensible.
Chelsea haven't given me any compelling evidence to back them recently, but I just have a feeling they will win this match because they are at home and they are overdue a victory.
Sutton's prediction: 2-1
Stingray's prediction: With this being at the Bridge, I am going to back Chelsea. I think they will start off really well and go 2-0 up, then Everton will nick one back but then Chelsea score late. 3-1
AI's prediction: 2-0
Liverpool vs Brighton
Anfield, 15:00 GMT
I am at this game and it will be intriguing to see what we get from the Reds.
It was great to see for Reds boss Arne Slot to get such a great win at Inter Milan on Tuesday following all the controversy with Mohamed Salah this week.
Slot should not have to put up with that nonsense. I know Salah has been a legend for the club but at its core Slot just wants to win games and there is nothing personal in his team selection.
They changed their formation against Inter and went with a midfield diamond formation and two up top.
All the talk is going to be talking about whether Salah is included for this game, but the only way he is going to be brought back into the fold is if he makes amends.
Slot's focus will be on winning this game, but it is a difficult fixture.
You could argue it is the same for most teams but I find Brighton so mercurial. I always feel they have got a goal in them, but they are defensively susceptible too.
Liverpool need to get back to winning consistently, but I am not sure how much their energy spent at the San Siro will have affected their stamina.
I've selected a couple of Brighton players in my FPL team, so they will likely do poorly - but I do fancy get something at Anfield.
Sutton's prediction: 2-2
Stingray's prediction: This is a game which is going to give Liverpool a bit more of their confidence back. Obviously they had a good win in midweek and they can build more momentum here. 2-1
AI's prediction: 3-1
Sunday, 14 December
Sunderland vs Newcastle
Stadium of Light, 14:00 GMT
The Wearside club have had the week off while Newcastle had to exert themselves against Bayer Leverkusen on Wednesday, only to concede a late equaliser late on.
Aside from their superb performance against Everton a couple of weeks ago, Newcastle's away form has been poor, especially straight after they've played in the Champions League.
I am expecting that trend to continue on Sunday, and their lack of freshness is likely to be a factor in how this game goes because of Sunderland's high press.
It was evident how unwavering Regis le Bris's side are. They dominated the Gunners, and it was amazing to watch.
Commentators talks about how Granit Xhaka has been outstanding for the Black Cats, and he has been superb, but Noah Sadiki, who plays next to him, has also been one of the top transfers and warrants praise too.
This promises to be this being the best game|most exciting fixture